Mesothelioma - What Causes Mesothelioma Other Than Asbestos? Asbestos is the sole cause of mesothelioma. It can cause damage to the linings of the lungs as well as the abdomen (peritoneal mesothelioma) and the heart (pericardial msothelioma). Other risk factors include radiation therapy for other cancers, genetics and asbestos-like minerals
